Trimethoprim

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PackageDosagePricePrice per Dose
Dosage: 400/80mg
292382360 pill400/80mgNZD571.57NZD1.59
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Dosage: 800/160mg
292389360 pill800/160mgNZD1,514.15NZD4.20
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29239520 pill800/160mgNZD113.53NZD5.60
29239610 pill800/160mgNZD56.74NZD5.68
Trimethoprim
Trimethoprim Description

Overview of Trimethoprim

Trimethoprim is a widely used antibiotic that belongs to the class of drugs known as dihydrofolate reductase inhibitors. It is primarily prescribed to treat bacterial infections, especially urinary tract infections (UTIs). The medication works by blocking the production of folic acid within bacteria, which is essential for their growth and survival. As a result, it effectively stops bacteria from multiplying and helps the body's immune system eliminate the infection.

Usage and Dosage

Trimethoprim is typically available in tablet form and is taken orally. The dosage prescribed depends on the type and severity of the infection. Patients are advised to follow the doctor's instructions carefully and complete the full course of treatment, even if symptoms improve before the medication is finished. This helps prevent the development of antibiotic-resistant bacteria. It is usually taken with a full glass of water, and sometimes alongside other medications like sulfamethoxazole, forming a combination therapy known as co-trimoxazole.

Benefits of Trimethoprim

One of the main advantages of trimethoprim is its effectiveness against common bacterial strains responsible for urinary tract infections. Many patients experience quick relief from symptoms such as burning sensations during urination, frequent urges to urinate, and lower abdominal pain after starting treatment. Its targeted action minimizes damage to beneficial bacteria in the body, reducing the risk of secondary infections or disruptions to the gut flora. When used correctly, trimethoprim can significantly shorten the duration of bacterial infections.

Possible Side Effects

Like all medications, trimethoprim may cause side effects in some individuals. Mild reactions include nausea, vomiting, rash, or itching. These typically resolve on their own or with minor medical adjustments. However, more serious side effects can occur, such as allergic reactions characterized by swelling, difficulty breathing, or severe skin rashes. Blood count abnormalities like anemia or leukopenia are rare but possible, especially if the medication is used over a prolonged period. Patients with existing kidney or liver problems should use trimethoprim cautiously and under medical supervision.

Precautions and Interactions

Before starting treatment with trimethoprim, it is essential to inform the healthcare provider of any allergies, current medications, or pre-existing health conditions. Certain drugs, such as methotrexate or other immunosuppressants, can interact with trimethoprim, increasing the risk of adverse effects. Patients taking blood thinners should be cautious because trimethoprim can alter blood clotting parameters. Pregnant women and nursing mothers should discuss potential risks with their doctor, as safety data is limited for these populations. Adequate hydration during therapy reduces the risk of kidney complications.

Effectiveness and Resistance Concerns

While trimethoprim remains an effective antibiotic against many bacterial strains, resistance development is an ongoing concern. Overuse or misuse of antibiotics contributes to bacteria evolving resistance mechanisms, rendering some drugs less effective over time. Healthcare providers monitor local resistance patterns and adjust treatment protocols accordingly. It is crucial for patients to use trimethoprim only when prescribed and to adhere strictly to recommended dosages to help preserve its efficacy.

Storage and Handling

Proper storage of trimethoprim ensures its potency and safety. The medication should be kept in a cool, dry place away from direct sunlight, and out of reach of children. Expired medications should be safely disposed of according to local regulations. Patients are advised to store the tablets in their original packaging to prevent contamination or mix-up with other medicines. If any adverse reactions are noticed or if the medication does not seem effective, consulting a healthcare professional is essential.

See Also

Bactrim
Bactrim

From NZD0.42 per dose