Package | Dosage | Price | Price per Dose | |
---|---|---|---|---|
Dosage: 5mg | ||||
360 pill | 5mg | NZD872.14 | NZD2.42 | |
180 pill | 5mg | NZD457.25 | NZD2.54 | |
120 pill | 5mg | NZD327.03 | NZD2.73 | |
90 pill | 5mg | NZD263.44 | NZD2.94 | |
60 pill | 5mg | NZD193.78 | NZD3.21 | |
30 pill | 5mg | NZD112.02 | NZD3.76 | |
Dosage: 10mg | ||||
120 pill | 10mg | NZD414.86 | NZD3.45 | |
90 pill | 10mg | NZD339.15 | NZD3.76 | |
60 pill | 10mg | NZD248.30 | NZD4.15 | |
30 pill | 10mg | NZD148.36 | NZD4.97 |

Donepezil Description
Overview of Donepezil
Donepezil is a widely used medication primarily prescribed for the treatment of Alzheimer's disease. It belongs to a class of drugs known as cholinesterase inhibitors. This medication works by increasing the levels of a neurotransmitter called acetylcholine in the brain, which is often deficient in individuals suffering from dementia. By enhancing communication between nerve cells, Donepezil can help improve cognitive functions and potentially slow the progression of symptoms associated with Alzheimer's disease.
How Donepezil Works
The primary mechanism of Donepezil involves the inhibition of the enzyme acetylcholinesterase. This enzyme is responsible for breaking down acetylcholine in the synapses of nerve cells. When the enzyme’s activity is reduced, acetylcholine remains active longer, facilitating better nerve signal transmission. This results in improved memory, attention, and other cognitive functions in patients diagnosed with early to moderate stages of Alzheimer’s. While it does not cure the disease, Donepezil can significantly enhance the quality of life for many users.
Benefits and Effectiveness
Many patients report noticeable improvements in memory, alertness, and daily functioning after starting Donepezil. Clinical studies have shown that the medication can temporarily stabilize or slow cognitive decline in some individuals. It is most effective when used early in the disease’s progression and often requires continuous administration to maintain benefits. Some users also experience better behavior and mood stability, which can contribute to more positive interactions with caregivers and family members.
Possible Side Effects
Like all medications, Donepezil may cause side effects in certain individuals. Common adverse effects include nausea, diarrhea, insomnia, dizziness, and muscle weakness. These symptoms are usually mild and tend to decrease over time or with dose adjustments. In some cases, more serious side effects such as heart rhythm problems or gastrointestinal bleeding may occur and require immediate medical attention. It's important for patients to discuss any side effects with their healthcare providers promptly.
Precautions and Considerations
Before starting Donepezil, patients should inform their healthcare provider of any existing medical conditions, including liver or heart problems. It is also important to mention any other medications being taken, as Donepezil can interact with various drugs, potentially leading to adverse reactions. Regular monitoring during treatment helps ensure the medication’s safety and effectiveness. Pregnant or breastfeeding women should consult their doctor before using Donepezil, as safety data in these populations is limited.
Usage and Dosage
Donepezil is typically prescribed in a gradual dose escalation to minimize side effects. The usual starting dose is 5 mg once daily, usually taken in the evening. Depending on individual response and tolerance, the dose may be increased to 10 mg once daily. Some patients might benefit from doses up to 23 mg daily, but higher doses are associated with increased side effects. It is crucial to follow the healthcare provider’s instructions carefully and not to adjust the dose without medical approval.
Conclusion
Donepezil remains a cornerstone in managing symptoms of Alzheimer’s disease. Its ability to enhance cholinergic function can provide meaningful benefits for patients in the early and moderate stages of dementia. However, careful consideration of potential side effects and constant medical supervision are essential for safe and effective treatment. As with any medication, adherence to prescribed dosages and regular follow-up consultations help maximize the benefits of Donepezil while minimizing risks.